New England Journal of Medicine

Background There is an urgent need to determine whether oversulfated chondroitin sulfate (OSCS), a compound contaminating heparin supplies worldwide, is the cause of the severe anaphylactoid reactions that have occurred ...

Early-onset, severe retinal dystrophy caused by mutations in the gene encoding retinal pigment epithelium-specific 65-kDa protein (RPE65) is associated with poor vision at birth and complete loss of vision in ...

Leber's congenital amaurosis (LCA) is a group of inherited blinding diseases with onset during childhood. One form of the disease, LCA2, is caused by mutations in the retinal pigment epithelium-specific ...

Background Bone mineral density influences the risk of osteoporosis later in life and is useful in the evaluation of the risk of fracture. We aimed to identify sequence variants associated ...

Background Neuroblastoma is a malignant condition of the developing sympathetic nervous system that most commonly affects young children and is often lethal. Its cause is not known.

Methods We performed ...

Background Antifibrinolytic agents are commonly used during cardiac surgery to minimize bleeding and to reduce exposure to blood products. We sought to determine whether aprotinin was superior to either tranexamic ...

On April 11, 2008, the National Vaccine Advisory Committee took an unusual step: in the name of transparency, trust, and collaboration, it asked members of the public to help set ...

Lately, I've been coming to work at midnight. You see, I've begun making late-night administrative rounds at the hospital where I am president and chief executive officer. No, I'm not ...

A 55-year-old bisexual man presented with a few weeks' history of lethargy followed by the onset of a widespread nonpruritic rash that covered much of his body, including the palms ...

A 24-year-old woman (gravida 0, para 0) presented with a history of progressive abdominal distention during the previous year, accompanied by early satiety and constipation. There was no history of ...

Drugs that are used to treat patients with human immunodeficiency virus (HIV) infection are classified according to their target. The first ones to be developed were nucleoside reverse-transcriptase inhibitors (NRTIs), ...

Guidelines for the assessment of cardiovascular risk remain focused squarely on established risk factors.1 Although it is known that tools based on these risk factors, such as the Framingham Risk ...

Intracerebral hemorrhage accounts for 10 to 15% of all strokes. It is the type of stroke with the highest mortality, with a 1-year survival rate of less than 50%.1 Most ...

To the Editor: We wish to express a number of concerns about the methods used in the study of mild ...

To the Editor: The acceptance of a partial face allograft as a promising procedure for patients with facial disfigurement will ...

To the Editor: The importance of the study reported by Turner et al. (Jan. 17 issue),1 on selective publication of ...

To the Editor: In their editorial about physicians and executions, Curfman et al. (Jan. 24 issue)1 are correct that our ...

To the Editor: I was deeply disturbed by the discussion, led by Gawande, on physicians and executions (Jan. 31 issue).1 ...

To the Editor: The Perspective article by Hunter et al. (Jan. 10 issue)1 concludes that commercialization of personal genomics is ...

To the Editor: Triptans are serotonin-receptor agonists used in the treatment of migraine headaches. When administered in combination with certain ...

This book about the ongoing revolution in human longevity and its implications for society was written by Robert Butler, a professor of geriatrics who is still working at the age ...

Human embryonic stem cells were isolated 10 years ago with the use of knowledge that had been gained from more than 20 years of research in rodents and nonhuman primates. ...

Like it or not, we are defined by being male or female. One of the first things children can tell you about themselves is their sex, and they are remarkably ...